RecruitingNCT06651333
fMRI and Opioid Abstinence
Functional Connectivity Mechanisms of Opioid Abstinence
Sponsor
Yale University
Enrollment
240 participants
Start Date
Dec 12, 2024
Study Type
OBSERVATIONAL
Conditions
Summary
This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.
Eligibility
Min Age: 18 YearsMax Age: 50 Years
Inclusion Criteria3
- recent initiation of methadone or buprenorphine at a clinic or program within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);
- eligibility for MRI scanning;
- ability to commit to study visits.
Exclusion Criteria6
- current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
- current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
- severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore <30 (i.e., severe impairment)
- past or present history of intellectual disability, developmental disorder, or neurological disease;
- head trauma with loss of consciousness >30 min;
- organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DIAGNOSTIC_TESTfMRI
Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task, Drug cue task, and Cognitive behavioral therapy task. Participants are not presented with any specific stimulus.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06651333
Related Trials
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
NCT060335992 locations
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
NCT037453391 location
Sex Hormones, Postoperative Pain and Opioid Use
NCT060232251 location
Opioid Dispensing Device for Post-Operative Pain in Cancer Patients
NCT055857881 location
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
NCT069811951 location