RecruitingNCT06651333

fMRI and Opioid Abstinence

Functional Connectivity Mechanisms of Opioid Abstinence

Sponsor

Yale University

Enrollment

240 participants

Start Date

Dec 12, 2024

Study Type

OBSERVATIONAL

Conditions

Opioid Use Opioid Dependence Opioid Abuse Opioid-Related Disorders Drug Use Disorder

Summary

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria3

recent initiation of methadone or buprenorphine at a clinic or program within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);
eligibility for MRI scanning;
ability to commit to study visits.

Exclusion Criteria6

current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore <30 (i.e., severe impairment)
past or present history of intellectual disability, developmental disorder, or neurological disease;
head trauma with loss of consciousness >30 min;
organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

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Interventions

DIAGNOSTIC_TESTfMRI

Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task, Drug cue task, and Cognitive behavioral therapy task. Participants are not presented with any specific stimulus.