Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
PANTHER Study: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress
Petter Bjornstad
100 participants
Sep 27, 2021
OBSERVATIONAL
Conditions
Summary
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
Eligibility
Inclusion Criteria4
- HbA1c ≥6.0% for untreated high-risk group
- BMI ≥ 85th %ile for high-risk group
- Normal HbA1c ≤5.6% for control group
- Type 1 diabetes (T1D) Antibody negative
Exclusion Criteria7
- History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
- Metabolic disorder prohibiting safe fasting
- Iodine or penicillin allergy
- Pregnancy
- Thrombophilia
- MRI contraindications
- Hormone therapy
Interventions
Diagnostic aid/agent used to measure effective renal plasma flow (ERPF)
Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
Diagnostic aid/agent used to measure glomerular size and selectivity
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05008276