Type 2 Diabetes Mellitus Clinical Trials

109 recruiting

Type 2 Diabetes Mellitus Trials at a Glance

161 actively recruiting trials for type 2 diabetes mellitus are listed on ClinicalTrialsFinder across 6 cities in 42 countries. The largest study group is Not Applicable with 55 trials, with the heaviest enrollment activity in Seoul, Houston, and Nanjing. Lead sponsors running type 2 diabetes mellitus studies include Hoffmann-La Roche, Bayer, and Nanjing First Hospital, Nanjing Medical University.

Browse type 2 diabetes mellitus trials by phase

Treatments under study

About Type 2 Diabetes Mellitus Clinical Trials

Looking for clinical trials for Type 2 Diabetes Mellitus? There are currently 109 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Type 2 Diabetes Mellitus trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Type 2 Diabetes Mellitus clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 161 trials

Recruiting
Phase 4

Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
University Medical Centre Ljubljana90 enrolled1 locationNCT06613854
Recruiting

POLUS: Description of the Effectiveness and Tolerability of Luseogliflozin in Patients With Type 2 Diabetes.

Type 2 Diabetes Mellitus
Servier Russia300 enrolled1 locationNCT07433192
Recruiting

Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa

ObesityCardiovascular DiseasesChronic Kidney Diseases+8 more
Swiss Tropical & Public Health Institute1,200 enrolled1 locationNCT05881447
Recruiting
Not Applicable

Culturally Tailored Program for Food-Insecure Adults: SPICE-D

Type 2 Diabetes Mellitus (T2D)
Wake Forest University Health Sciences25 enrolled1 locationNCT07361341
Recruiting

Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus

DiabetesType 2 Diabetes Mellitus (T2DM)Diabetic Retinopathy
Yufan Wang2,920 enrolled3 locationsNCT06821399
Recruiting
Phase 3

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

Obesity or OverweightType 2 Diabetes Mellitus
Hoffmann-La Roche1,600 enrolled36 locationsNCT07351058
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting

An Observational Study Called FINE-REAL Korea to Learn More About the Use of the Drug Finerenone in People With Chronic Kidney Disease and Type 2 Diabetes in a Routine Medical Care Setting in South Korea

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer500 enrolled1 locationNCT07232537
Recruiting
Not Applicable

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Hoffmann-La Roche270 enrolled16 locationsNCT06704672
Recruiting

A Study of Glycemic Control in Left Ventricular Assist

HyperglycemiaHypoglycemiaType 2 Diabetes Mellitus
Mayo Clinic20 enrolled1 locationNCT05933161
Recruiting
Phase 1

Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers

Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled6 locationsNCT06906627
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled6 locationsNCT06906640
Recruiting
Not Applicable

Impact of Pilates Exercises on Diabetic Erectile Dysfunction.

Pilates ExerciseDiabete MellitusErectile Dysfunction Associated With Type 2 Diabetes Mellitus+1 more
Benha University60 enrolled2 locationsNCT07293156
Recruiting

Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Exocrine Pancreatic Insufficiency (EPI)Pancreatogenic Diabetes Mellitus
West Kazakhstan Marat Ospanov Medical University310 enrolled1 locationNCT07512934
Recruiting
Phase 4

The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)SemaglutideCaloric Restriction
Second Affiliated Hospital of Nanchang University100 enrolled1 locationNCT07272343
Recruiting

An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer50,000 enrolled4 locationsNCT06278207
Recruiting
Not Applicable

Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia

SarcopeniaType 2 Diabetes Mellitus (T2DM)
yueh chu wu128 enrolled1 locationNCT07398495
Recruiting
Not Applicable

Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

Arterial StiffnessAdultOverweight+13 more
Georgia State University40 enrolled1 locationNCT06735599