Type 2 Diabetes Mellitus Clinical Trials

183 recruitingLast updated: June 18, 2026

There are 183 actively recruiting type 2 diabetes mellitus clinical trials across 44 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4, Phase 3. Top locations include Houston, Texas, United States, Nanjing, Jiangsu, China, Seoul, South Korea. Updated daily from ClinicalTrials.gov.


Type 2 Diabetes Mellitus Trials at a Glance

183 actively recruiting trials for type 2 diabetes mellitus are listed on ClinicalTrialsFinder across 6 cities in 44 countries. The largest study group is Not Applicable with 67 trials, with the heaviest enrollment activity in Houston, Nanjing, and Seoul. Lead sponsors running type 2 diabetes mellitus studies include Hoffmann-La Roche, Bayer, and Nanjing First Hospital, Nanjing Medical University.

Browse type 2 diabetes mellitus trials by phase

Treatments under study

About Type 2 Diabetes Mellitus Clinical Trials

Looking for clinical trials for Type 2 Diabetes Mellitus? There are currently 113 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Type 2 Diabetes Mellitus trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Type 2 Diabetes Mellitus clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 183 trials

Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled7 locationsNCT06906640
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled7 locationsNCT06906627
Recruiting
Not Applicable

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Hoffmann-La Roche270 enrolled18 locationsNCT06704672
Recruiting

An Observational Study Called FINE-REAL Korea to Learn More About the Use of the Drug Finerenone in People With Chronic Kidney Disease and Type 2 Diabetes in a Routine Medical Care Setting in South Korea

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer500 enrolled1 locationNCT07232537
Recruiting
Not Applicable

DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

Obesity, OverweightAsthma (Diagnosis)Type 1 Diabetes+3 more
Adhera Health, Inc.280 enrolled1 locationNCT07638345
Recruiting

Validity and Reliability of Mixed Reality-Based Functional Mobility Tests in Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
Selcuk University75 enrolled1 locationNCT07649967
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Not Applicable

Impact of Pilates Exercises on Diabetic Erectile Dysfunction.

Pilates ExerciseDiabete MellitusErectile Dysfunction Associated With Type 2 Diabetes Mellitus+1 more
Benha University60 enrolled2 locationsNCT07293156
Recruiting
Not Applicable

Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy

ObesityObesity Type 2 Diabetes Mellitus
University of South Carolina50 enrolled1 locationNCT07518407
Recruiting
Not Applicable

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

Obesity, OverweightDehydrationType 2 Diabetes+2 more
State University of New York at Buffalo30 enrolled1 locationNCT07641361
Recruiting
Not Applicable

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Medtronic MiniMed, Inc.400 enrolled38 locationsNCT07228117
Recruiting
Not Applicable

Achieving Routine Intervention and Screening for Emotional Health

Type 2 Diabetes Mellitus (T2DM)Diabetes Distress
University of Chicago1,250 enrolled1 locationNCT06887049
Recruiting

Diagnostic Value of the Liver Inflammation Index for MASH in Patients With T2DM and MAFLD

Type 2 Diabetes Mellitus (T2DM)MASH - Metabolic Dysfunction-Associated SteatohepatitisMetabolic Dysfunction-associated Fatty Liver Disease
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School10,000 enrolled22 locationsNCT07632677
Recruiting

Eating Behaviour Before, During, and After Obesity Medication

Obesity, OverweightObesity Type 2 Diabetes Mellitus
University College Dublin30 enrolled1 locationNCT07636395
Recruiting
Phase 2

A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus

MASH - Metabolic Dysfunction-Associated SteatohepatitisT2DM (Type 2 Diabetes Mellitus)
Shanghai Jiao Tong University School of Medicine300 enrolled17 locationsNCT07303803
Recruiting
Not Applicable

Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Insulet Corporation200 enrolled12 locationsNCT07579702
Recruiting
Not Applicable

Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

Type 2 Diabetes Mellitus
Insulet Corporation350 enrolled15 locationsNCT07521475
Recruiting
Phase 4

SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes

AtherosclerosisType 2 Diabetes Mellitus (T2DM)Coronary Artery Disease
Junjie Yang144 enrolled2 locationsNCT07614230