RecruitingNot ApplicableNCT05010356

Insulin Sensitivity After Breast Cancer

Study of Molecular Causes of Metabolic Disorders in Obese Premenopausal Women After Breast Cancer

Sponsor

University of Copenhagen

Enrollment

24 participants

Start Date

Aug 1, 2021

Study Type

INTERVENTIONAL

Conditions

Breast Cancer Insulin Sensitivity/Resistance Survivorship Metabolic Disturbance

Summary

Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the major site of glucose uptake in humans. The aims of the present project are to 1) determine the involvement of insulin resistance in skeletal muscle in the metabolic disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular changes in skeletal muscle from BC survivors .

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study measures insulin sensitivity (how well the body responds to insulin) in premenopausal women after completing chemotherapy for breast cancer, compared to healthy women of similar age and body weight. The goal is to understand how cancer treatment affects metabolism and diabetes risk. **You may be eligible if...** - You are a premenopausal woman who has completed chemotherapy for breast cancer - It has been at least 3 weeks since your last chemotherapy session - Your BMI is between 25 and 30 - Healthy women with similar characteristics (age, weight, activity level) may also participate as controls **You may NOT be eligible if...** - You were already postmenopausal at the time of your breast cancer diagnosis - You drink more than 7 alcoholic beverages per week - You are a smoker - You already have Type 2 diabetes or metabolic syndrome - You have cardiovascular disease - You have limited mobility Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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