RecruitingPhase 2NCT05011227

Camrelizumab and Chemotherapy Combined With Endoscopic Surgery for Recurrent Nasopharyngeal Carcinoma

A Prospective, Single-arm, Multi-center Clinical Study of Camrelizumab and Chemotherapy Combined With Endoscopic Surgery in the Treatment of Recurrent Nasopharyngeal Carcinoma


Sponsor

Eye & ENT Hospital of Fudan University

Enrollment

100 participants

Start Date

Aug 10, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

To explore the effect of Camrelizumab and chemotherapy combining with endoscopic surgery in the treatment of recurrent nasopharyngeal carcinoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination of immunotherapy (camrelizumab), chemotherapy, and endoscopic surgery for people with nasopharyngeal carcinoma (cancer at the back of the nose) that has come back after initial treatment. **You may be eligible if...** - You are 18 or older - You have been diagnosed with recurrent nasopharyngeal carcinoma confirmed by biopsy - Your cancer can be surgically removed (specific tumor stages apply) - Your cancer came back at least 6 months after your first radiation treatment - You have no distant spread (metastasis) of the cancer - You have no recent risk of severe bleeding **You may NOT be eligible if...** - Your cancer has spread to distant parts of the body - Your cancer recurred less than 6 months after initial radiation - Your tumor is too advanced to be surgically removed - You have severe heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGCamrelizumab

2 cycles Camrelizumab before endoscopic surgery and one year after

DRUGChemotherapy

2 cycles Gemcitabine based chemotherapy before endoscopic surgery, with or without after surgery

PROCEDUREendoscopic surgery

standard endoscopic surgery for recurrent nasopharyngeal carcinoma


Locations(7)

The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, China

Shenzhen Second People's Hospital

Shenzhen, Guangdong, China

Fujian Medical University Union Hospital

Fuzhou, Fujian, China

Fujian Provincial Hospital

Fuzhou, Fujian, China

Eye& ENT Hospital, Fudan University

Shanghai, Shanghai Municipality, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Shanghai Zhongshan Hospital,Fudan University

Shanghai, Shanghai Municipality, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05011227


Related Trials