Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome

This study uses customized computer-based games — a type of modified virtual reality — to help individuals with Rett syndrome improve independent arm and hand use and reduce repetitive hand movements (stereotypies), which are hallmark symptoms of this rare genetic neurological condition. The study is conducted entirely via telehealth, allowing families from across the United States and multiple countries to participate from home. Individuals with Rett syndrome who understand cause and effect and have enough arm range of motion to interact with the games may be eligible, while those with a separate orthopedic or neuromuscular condition affecting shoulder movement are excluded. Participation involves playing customized games online for 1 hour, 3 days per week for approximately 12 weeks, with assessments of arm function and quality of life goals before and after. This summary was generated with AI assistance to help patients understand the study in plain language.