Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction
Immunometabolic Mechanisms of Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction
Yale University
20 participants
Feb 16, 2023
INTERVENTIONAL
Conditions
Summary
This is a crossover phase 4 study to evaluate the impact of blood flow restriction on immunometabolism and gene expression in immune cells in individuals undergoing rehabilitation from anterior cruciate ligament reconstruction.
Eligibility
Inclusion Criteria4
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart
- All genders, between 18 and 60 years of age
- In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study
Exclusion Criteria10
- Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.
- Multiple ligament ruptures or trauma
- Rheumatoid arthritis or other significant comorbidities
- Lower extremity vascular pathology, including history of deep vein thrombosis
- Those with a history of sickle cell trait or disease
- Use of anticoagulant medications
- Pregnancy
- Treatment with another investigational drug or other intervention within one month of Study Day 1
- Current smoker or tobacco use within 3 months of Study Day 1
- Febrile illness within 2 weeks of Study Day 1
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Interventions
The AirBands will be placed at each of the two training sessions and inflated while an ultrasound probe is placed over the femoral artery. The cuff will be inflated until the artery reaches 60% occlusion. The force will be applied using a wireless Bluetooth signal; participants will not be asked to adjust the device. Participants will be observed by a certified Personal Therapist throughout the training session in order to determine compliance and ensure safety as is standard protocol for a physical therapy session.
Uninflated AirBand will be used as the control intervention during the session in which BFR is not performed
Locations(2)
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NCT05012982