Anterior cruciate ligament reconstruction Clinical Trials

34 recruitingLast updated: June 20, 2026

There are 34 actively recruiting anterior cruciate ligament reconstruction clinical trials across 16 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 4. Top locations include Valencia, Valencia, Spain, Veranópolis, Rio Grande do Sul, Brazil, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Anterior cruciate ligament reconstruction Trials at a Glance

34 actively recruiting trials for anterior cruciate ligament reconstruction are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 23 trials, with the heaviest enrollment activity in Valencia, Veranópolis, and New York. Lead sponsors running anterior cruciate ligament reconstruction studies include Federal University of Health Science of Porto Alegre, University Ghent, and Assaf-Harofeh Medical Center.

Browse anterior cruciate ligament reconstruction trials by phase

Treatments under study

About Anterior cruciate ligament reconstruction Clinical Trials

Looking for clinical trials for Anterior cruciate ligament reconstruction? There are currently 30 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anterior cruciate ligament reconstruction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anterior cruciate ligament reconstruction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting
Not Applicable

Tourniquet vs. Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction

Anterior cruciate ligament reconstruction
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer128 enrolled3 locationsNCT06819696
Recruiting
Not Applicable

Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction

Anterior cruciate ligament reconstruction
NYU Langone Health100 enrolled1 locationNCT07217613
Recruiting
Not Applicable

Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationQuadriceps Muscle Function
Arcadia University42 enrolled1 locationNCT07128602
Recruiting
Not Applicable

Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
Universidade Estadual de Londrina20 enrolled3 locationsNCT06809920
Recruiting
Not Applicable

Effectiveness of Stimulation on the Sciatic Nerve in ACLR

Anterior Cruciate Ligament Reconstruction Rehabilitation
Universidad de Murcia62 enrolled1 locationNCT07569796
Recruiting
Not Applicable

ACL Reconstruction Rehabilitation With Exercise and Psychological Support

Anterior Cruciate Ligament Reconstruction Rehabilitation
HealthPartners Institute60 enrolled1 locationNCT06991192
Recruiting
Not Applicable

The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)

Anterior cruciate ligament reconstruction
Assaf-Harofeh Medical Center40 enrolled1 locationNCT06493851
Recruiting
Phase 1

Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells

Anterior cruciate ligament reconstruction
The Methodist Hospital Research Institute15 enrolled1 locationNCT06798623
Recruiting

Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationAnterior Cruciate Ligament (ACL) Reconstruction SurgeryStrength Outcomes
Hacettepe University80 enrolled1 locationNCT07523854
Recruiting
Not Applicable

Validating the Speckle Tracking Methods on Soft Tissue Strain, Displacement, and Roles in Physical Therapy

Anterior Cruciate Ligament Reconstruction RehabilitationUltrasound EvaluationUlnar Collateral Ligament Sprain+1 more
National Taiwan University Hospital80 enrolled1 locationNCT07485530
Recruiting
Not Applicable

Effectiveness of Blood Flow Restriction in Postoperative Rehabilitation for Anterior Cruciate Ligament Injuries. A Pilot Study.

Anterior Cruciate Ligament Reconstruction Rehabilitation
University of Valencia40 enrolled1 locationNCT06762392
Recruiting
Phase 2

The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients

Anterior cruciate ligament reconstruction
Stanford University50 enrolled1 locationNCT03552705
Recruiting
Not Applicable

ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws

Anterior cruciate ligament injuryAnterior cruciate ligament ruptureAnterior cruciate ligament reconstruction
Alexander Rofner-Moretti80 enrolled1 locationNCT06357091
Recruiting
Not Applicable

Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction

Anterior cruciate ligament reconstruction
Yale University20 enrolled2 locationsNCT05012982
Recruiting
Not Applicable

Effects of tDCS on Motor Cortex During ACL Recovery

Anterior Cruciate Ligament Reconstruction Rehabilitation
Fundación Universidad Católica de Valencia San Vicente Mártir54 enrolled1 locationNCT06818201
Recruiting
Not Applicable

Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction

Anterior cruciate ligament reconstructionAnterior Cruciate Ligament Reconstruction RehabilitationAthlete
Egas Moniz - Cooperativa de Ensino Superior, CRL36 enrolled1 locationNCT07243535
Recruiting
Phase 4

Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees

Anterior cruciate ligament reconstructionMedial Patellofemoral Ligament Reconstruction
Hospital for Special Surgery, New York60 enrolled1 locationNCT06590402
Recruiting
Not Applicable

Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament InjuriesAnterior cruciate ligament reconstruction
Chang Gung Memorial Hospital40 enrolled1 locationNCT06341192
Recruiting
Not Applicable

Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
University of North Carolina, Chapel Hill30 enrolled1 locationNCT07058467
Recruiting
Not Applicable

Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol

Anterior cruciate ligament reconstruction
University of Connecticut40 enrolled1 locationNCT05968729