Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
McGill University Health Centre/Research Institute of the McGill University Health Centre
1,300 participants
Sep 1, 2022
INTERVENTIONAL
Conditions
Summary
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Implantation of a left bundle branch pacing lead via sheath, to perform selective or non-selective pacing
Active fixation lead (standard)
Locations(1)
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NCT05015660