Non-Invasive Method for Evaluation of Cardiac Resynchronization Therapy
Oslo University Hospital
80 participants
Mar 21, 2023
OBSERVATIONAL
Conditions
Summary
Left bundle branch block (LBBB) exists in about 25% of patients with congestive heart failure and is associated with worsened prognosis. Cardiac resynchronization therapy (CRT) has been one of the most important advancements in the past two decades for patients with LBBB heart failure. However, 30-40% of patients receiving a CRT do not benefit from it. In this study, the investigators will test a noninvasive device to evaluate acute effect of CRT during implantation and at follow-up CRT controls. In addition, echocardiography will be performed during CRT turned ON and OFF to visualize the changes in intraventricular flow and functional parameters of the heart.
Eligibility
Inclusion Criteria8
- Patients referred for CRT implantation or postoperative control at Oslo University Hospital based on the European Society of Cardiology (ESC) guidelines (2021), and criteria below:
- Sinus rhythm.
- New York Heart Association class II / III heart failure on diagnosis and on optimal medical therapy.
- Left bundle branch block.
- QRS duration ≥ 130 ms.
- Left ventricular ejection fraction ≤ 40%.
- Patients must have echocardiography examination before implantation
- Informed consent obtained from the patient.
Exclusion Criteria3
- Age \< 18 years and \> 80 years;
- Ongoing atrial fibrillation;
- Complete atrioventricular block
Interventions
Cardiac resynchronization therapy (CRT) is a modality of cardiac pacing used in patients with left ventricular (LV) systolic dysfunction and dyssynchronous ventricular activation that provides simultaneous or nearly simultaneous electrical activation of the LV and right ventricle (RV) via stimulation of the LV and RV (biventricular pacing) or LV alone.
Locations(1)
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NCT05868616