RecruitingNCT05868616

Non-Invasive Method for Evaluation of Cardiac Resynchronization Therapy

Sponsor

Oslo University Hospital

Enrollment

80 participants

Start Date

Mar 21, 2023

Study Type

OBSERVATIONAL

Conditions

Heart Failure Cardiomyopathies Cardiovascular Diseases Heart Diseases Pacemaker DDD

Summary

Left bundle branch block (LBBB) exists in about 25% of patients with congestive heart failure and is associated with worsened prognosis. Cardiac resynchronization therapy (CRT) has been one of the most important advancements in the past two decades for patients with LBBB heart failure. However, 30-40% of patients receiving a CRT do not benefit from it. In this study, the investigators will test a noninvasive device to evaluate acute effect of CRT during implantation and at follow-up CRT controls. In addition, echocardiography will be performed during CRT turned ON and OFF to visualize the changes in intraventricular flow and functional parameters of the heart.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a non-invasive monitoring method to evaluate how well cardiac resynchronisation therapy (CRT) — a type of pacemaker that helps the two sides of the heart beat in sync — is working in people with heart failure. **You may be eligible if...** - You are being referred for CRT pacemaker implantation or a follow-up check at Oslo University Hospital - You have heart failure with a weakened pumping function (ejection fraction 40% or less) - You are in normal heart rhythm (not atrial fibrillation) - You have a specific electrical conduction problem called left bundle branch block with a QRS duration of 130ms or more - You are in NYHA class II or III heart failure on optimal medical therapy **You may NOT be eligible if...** - You do not meet the standard guidelines for CRT - You are unable to undergo an echocardiogram before implant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICECardiac Resynchronization Therapy (CRT)

Cardiac resynchronization therapy (CRT) is a modality of cardiac pacing used in patients with left ventricular (LV) systolic dysfunction and dyssynchronous ventricular activation that provides simultaneous or nearly simultaneous electrical activation of the LV and right ventricle (RV) via stimulation of the LV and RV (biventricular pacing) or LV alone.