Microbiome and Association With Implant Infections
Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction
University of California, San Francisco
200 participants
Sep 28, 2021
INTERVENTIONAL
Conditions
Summary
The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.
Eligibility
Inclusion Criteria5
- Patients must have histologically confirmed breast malignancy OR genetic predisposition to breast cancer.
- Age \>= 18 years
- Scheduled to undergo mastectomy with the immediate placement of tissue expanders or implant placement
- Ability to understand a written informed consent document, and the willingness to sign it
- At least 4 weeks post-completion of chemotherapy or radiation therapy.
Exclusion Criteria6
- Any significant medical condition or laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study
- Pregnant or breastfeeding
- Patients who have taken antibiotics within 90 days of the consent date
- Patients who have taken probiotics within 90 days of the consent date
- Patients who have a documented or reported allergic reaction to the outlined antibiotics to be used in this study
- Male patients
Interventions
Given orally (PO)
Locations(1)
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NCT05020574