Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant Bronchopulmonary Dysplasia (BPD, Also Known as Chronic Lung Disease of Prematurity) Through Exercise (FLASHLITE)
Masonic Cancer Center, University of Minnesota
90 participants
Mar 14, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))
Eligibility
Inclusion Criteria19
- Cases:
- Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
- years old
- Height: ≥ 48 inches
- Ambulatory without assistance
- English speaking
- Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
- SpO2 \>92%
- Not pregnant
- ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
- Controls
- years old
- Height: ≥ 48 inches
- Ambulatory without assistance
- English speaking
- No history of arrhythmia or known cardiac dysfunction at baseline
- Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
- SpO2 \>95%
- Not pregnant
Exclusion Criteria6
- Cases:
- ALL specific: received cranial radiation, bone marrow transplant recipients
- Investigator or patient's primary physician deems the patient unsuitable for the study
- Controls:
- History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
- Investigator deems the patient unsuitable for the study
Interventions
Participant Reported Physical Activity and Outcomes (completed via REDCap or on paper)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05025774