Two Step Haplo With Radiation Conditioning

This trial uses a "two-step" bone marrow transplant approach — called haploidentical (half-matched donor) transplantation — as a treatment for blood cancers. The unique method separates immune cell infusion into two steps to reduce the risk of graft-versus-host disease while still fighting the cancer. It is designed for patients who need a transplant but can't find a fully matched donor. **You may be eligible if...** - You have a blood cancer such as AML, ALL, MDS, lymphoma, multiple myeloma, or a related condition - You have a family member who is a half-matched (haploidentical) donor - Your cancer is considered potentially curable with a bone marrow transplant - You may also qualify if prior radiation or past transplants prevent you from receiving a standard high-intensity regimen **You may NOT be eligible if...** - You do not have a suitable haploidentical donor - Your cancer is too advanced or your overall health is too poor for a transplant - Your disease is not on the list of eligible diagnoses Talk to your doctor to see if this trial is right for you.