RecruitingNCT05032768

The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients

The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients Receiving Radiation After Mastectomy and Reconstructive Surgery


Sponsor

Fudan University

Enrollment

100 participants

Start Date

Jan 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The breast cancer patients who received radiotherapy after mastectomy and breast reconstruction will be enrolled. The skin microbiome before radiotherapy and its changes after radiotherapy will be analyzed systematically to find out whether the skin microbiome is associated with the severity of radiation dermatitis.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This Chinese study looks at whether changes in the skin bacteria (the skin microbiome) are linked to the development or severity of radiation dermatitis — the painful skin inflammation that can occur during radiotherapy. It studies breast cancer patients receiving chest radiation after mastectomy and reconstruction. **You may be eligible if...** - You are a female patient - You have invasive breast cancer confirmed by pathology - You had a mastectomy followed by breast reconstruction - You are scheduled to receive radiation therapy after reconstruction - You are in good general health (ECOG 0–1) **You may NOT be eligible if...** - You have previously received radiation to the breast or chest - You have a serious skin disease (such as lupus or scleroderma) that would interfere with radiotherapy - You are pregnant - You are unwilling or unable to attend regular follow-up appointments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONpost-operative radiotherapy

Breast cancer patients who have received reconstructive surgery will receive post-operative radiotherapy.


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

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NCT05032768


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