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RecruitingNCT05032768

The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients

The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients Receiving Radiation After Mastectomy and Reconstructive Surgery

Sponsor

Fudan University

Enrollment

100 participants

Start Date

Jan 1, 2021

Study Type

OBSERVATIONAL

Conditions

Breast CancerSkin MicrobiomeRadiation DermatitisReconstructive Surgery

Summary

The breast cancer patients who received radiotherapy after mastectomy and breast reconstruction will be enrolled. The skin microbiome before radiotherapy and its changes after radiotherapy will be analyzed systematically to find out whether the skin microbiome is associated with the severity of radiation dermatitis.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Inclusion Criteria6

  • Female patients
  • Invasive breast cancer confirmed by pathology
  • Underwent mastectomy and breast reconstruction
  • Radiotherapy after breast reconstruction
  • ECOG score 0-1
  • Signed informed consent

Exclusion Criteria4

  • Previous breast or chest radiotherapy
  • Other serious skin diseases (systemic lupus erythematosus, skin sclerosis, et al) and cannot receive radiotherapy
  • Pregnant women
  • Patients who are unwilling or unable to receive regular follow-up.

Interventions

RADIATIONpost-operative radiotherapy

Breast cancer patients who have received reconstructive surgery will receive post-operative radiotherapy.

Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

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NCT05032768

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