COAST Therapy in Advanced Solid Tumors and Prostate Cancer

This trial is testing a combination therapy called COAST — using existing drugs including nelfinavir — in people with advanced solid tumors (Phase I) or advanced prostate cancer (Phase II) whose cancer has continued to grow despite prior treatments. **You may be eligible if...** - You are 18 or older with advanced solid tumor cancer or advanced prostate cancer - Your cancer has progressed on at least one prior treatment - You are reasonably functional (ECOG status 0–2) - Your blood counts, kidney, and liver function meet minimum thresholds - Your blood sugar is reasonably controlled **You may NOT be eligible if...** - You have significant heart disease (heart failure, recent heart attack, unstable heart rhythm) - You have had radiotherapy, surgery, or another experimental treatment within 28 days - You have active, uncontrolled infections - You are taking blood-thinning drugs like warfarin, apixaban, or rivaroxaban - You have a serious psychiatric condition - You are currently in another clinical trial - You are a prisoner or under compulsory detention Talk to your doctor to see if this trial is right for you.