RecruitingNCT05038553

Chronic Pain in Rheumatoid Arthritis

CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain Transition

Sponsor

Northwestern University

Enrollment

125 participants

Start Date

Oct 12, 2021

Study Type

OBSERVATIONAL

Conditions

Pain Arthritis, Rheumatoid

Summary

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Eligibility

Min Age: 18 Years

Inclusion Criteria10

Age ≥18 years
Meet either the 1987 or 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria for RA
Persistent joint symptoms ≤ 2 years
Active inflammatory disease
If taking opioids on an as needed (prn) basis, must be able to hold opioid for 12 hours before study procedures
If taking NSAIDs, must be able to hold NSAIDS for 24 hours before study procedures
If taking a central-acting pain medication, must be on a stable dose and able to stay on a stable dose throughout study
Age ≤ 80 years old
Right-handed or ambidextrous
Ability to lie on their back for the duration of the MRI scans

Exclusion Criteria10

Routine, scheduled opioid use
Routine, scheduled prednisone dose \>10 mg or its equivalent
Peripheral neuropathy
Peripheral vascular disease
Raynaud's phenomenon requiring treatment, manifested by claudication or ischemic rest pain
Uncontrolled blood pressure
Severe claustrophobia precluding MRI
Unable to fit comfortably in the MRI scanner (usually only occurs if body mass index \>40 kg/m2)
Pregnant
Contraindications to MRI

Interventions

OTHERNo intervention

No intervention

Locations(5)

University of Colorado

Denver, Colorado, United States

Northwestern University

Chicago, Illinois, United States

Johns Hopkins University

Baltimore, Maryland, United States

University of Michigan

Ann Arbor, Michigan, United States

Hospital for Special Surgery

New York, New York, United States

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NCT05038553

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