Safety of Allogeneic Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) to Treat Perianal Fistulas w/ Crohn's Disease

This trial is testing the safety of stem cell therapy using cells from umbilical cord donors to treat complex anal fistulas — abnormal tunnels between the inside of the bowel and the skin around the anus — in patients with Crohn's disease who have not responded to medications. **You may be eligible if...** - You are 18 or older - You have Crohn's disease with anal fistulas that have not responded to medical treatment - You have no more than 2 internal and 3 external fistula openings - You are well enough to undergo surgery **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an active cancer or were in remission from cancer less than 5 years ago - You have active sepsis or a significant local infection - You have HIV, hepatitis B or C, or syphilis - You have known severe allergies - You have received certain biologic drugs (like infliximab) in the past 4 weeks - You have been in another clinical trial in the past month Talk to your doctor to see if this trial is right for you.