DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease

This study is testing a new treatment called DB-3Q bmMSC-EVs — tiny particles derived from stem cells — injected directly into perianal fistulas in people with Crohn's disease. Perianal fistulas are tunnels forming near the anus that are a painful, hard-to-treat complication of Crohn's. **You may be eligible if...** - You are between 18 and 75 years old and have had Crohn's disease for at least 6 months - You have 1 or more actively draining perianal fistulas with 2 or fewer openings - You have tried and failed at least one prior medical treatment (antibiotics, immunosuppressants, or biologics) - You have either tried and failed surgical treatment or are not a candidate for or willing to undergo surgery - Your Crohn's medical therapy has been stable for at least 2 months **You may NOT be eligible if...** - You are pregnant or could become pregnant without using contraception - Your fistula is currently infected or has an abscess that has not been adequately treated Talk to your doctor to see if this trial is right for you.