Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial

This trial is comparing two standard immune-suppressing drugs — azathioprine versus methotrexate — when added to adalimumab (a biologic injection) for the treatment of moderate-to-severe Crohn's disease to find out which combination works better. **You may be eligible if...** - You are over 18 with a diagnosis of Crohn's disease for at least 6 weeks - Your Crohn's disease is currently active (CDAI score above 150) with confirmed active inflammation on colonoscopy - You have not responded to or cannot tolerate conventional Crohn's medications - You are starting adalimumab treatment - You use effective contraception if applicable **You may NOT be eligible if...** - You have short bowel syndrome, ostomy, bowel obstruction, abscess, or recent abdominal surgery (within 3 months) - You have previously had a bad reaction to azathioprine (thiopurines) or methotrexate - You are pregnant or planning to become pregnant - You have serious liver, kidney, or blood problems Talk to your doctor to see if this trial is right for you.