Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
Finding Treatments for COVID-19: A Phase 2 Multi-centre Adaptive Platform Trial to Assess Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
University of Oxford
3,800 participants
Sep 30, 2021
INTERVENTIONAL
Conditions
Summary
The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19 to determine in-vivo antiviral activity. In this randomized open label, controlled, group sequential adaptive platform trial, we will assess the performance of three distinct types of intervention relative to control (no treatment): A: Small molecule drugs; B: Monoclonal antibodies; C: Dose finding for the constituent parts of nirmatrelvir/ritonavir PLATCOV study is supported by the Wellcome Trust Grant ref: 223195/Z/21/Z through the COVID-19 Therapeutics Accelerator.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Nirmatrelvir 300mg BD for 5/7 Ritonavir 100mg BD for 5/7
Nitazoxanide 1.5g BD 7/7
Molnupiravir 800mg BD for 5/7, Nirmatrelvir 300mg BD for 5/7, Ritonavir 100mg BD for 5/7
Hydroxychloroquine 400mg D0 BD and 400MG OD for a further 6/7
No treatment (except antipyretics- paracetamol)
Monoclonal antibodies: 300mg tixagevimab/ 300 mg cilgavimab given once on D0
Fluoxetine 40mg OD for 7/7
Molnupiravir 800mg BD for 5/7
Sotrovimab 500mg given once on D0
Ensitrelvir 375mg OD D0 and 125mg OD for a further 4/7
Monoclonal antibodies: 600mg casirivimab/ 600mg imdevimab given once on D0
Favipiravir 1800mg BD D0 and 800mg BD for a further 6/7
Ivermectin 600micrograms/kg/day for 7/7.
Remdesivir 200mg D0 and 100mg for a further 4/7.
Atilotrelvir 150mg BD for 5/7 Ritonavir 100mg BD for 5/7
Metformin 500mg TDS 5/7
Nirmatrelvir 300mg BD for 5/7 Ritonavir 50mg BD for 5/7
Nirmatrelvir 150mg BD for 5/7 Ritonavir 50mg BD for 5/7
Nirmatrelvir 300mg BD for 5/7
Locations(7)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05041907