COVID-19 Clinical Trials

260 recruiting

COVID-19 Trials at a Glance

221 actively recruiting trials for covid-19 are listed on ClinicalTrialsFinder across 6 cities in 76 countries. The largest study group is Not Applicable with 60 trials, with the heaviest enrollment activity in Houston, Chicago, and Baltimore. Lead sponsors running covid-19 studies include National Institute of Allergy and Infectious Diseases (NIAID), M.D. Anderson Cancer Center, and Pfizer.

Browse covid-19 trials by phase

Treatments under study

About COVID-19 Clinical Trials

Looking for clinical trials for COVID-19? There are currently 260 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new COVID-19 trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about COVID-19 clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 221 trials

Recruiting
Phase 1

A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes

COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)140 enrolled8 locationsNCT07221162
Recruiting

Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome

Post-Acute COVID-19 Vaccination SyndromePostviral Fatigue
University of Bern200 enrolled1 locationNCT07400848
Recruiting

International Survey of Acute Coronavirus Syndromes-COVID-19

COVID-19
University of Bologna10,000 enrolled2 locationsNCT05188612
Recruiting

Impact of the Coronavirus (COVID-19) on Patients With Cancer

CancerCOVID-19
Stanford University50 enrolled1 locationNCT04330521
Recruiting
Phase 3

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

COVID-19 Infection
Pfizer300 enrolled132 locationsNCT07013474
Recruiting
Phase 1

A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir

COVID-19 (Coronavirus Disease 2019)Coronavirus Disease 2019Coronavirus Disease 2019 (COVID-19)
Pfizer18 enrolled1 locationNCT07552779
Recruiting
Phase 3

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Coronavirus Disease (COVID-19)
Merck Sharp & Dohme LLC3,082 enrolled222 locationsNCT06667700
Recruiting

Physical Functions and Lifestyle Behaviours in Post-COVID-19 Syndrome Based on Circadian Rhythms

Post-COVID-19 Syndrome
Hacettepe University50 enrolled1 locationNCT07545499
Recruiting
Phase 1

Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults

COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)60 enrolled3 locationsNCT07183709
Recruiting

Well-Being and Health-Related Quality of Life in Melanoma Patients During COVID-19 Pandemic

MelanomaCOVID-19 Infection
M.D. Anderson Cancer Center1,152 enrolled1 locationNCT04474301
Recruiting

Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)ME/CFS Following COVID-19
Charite University, Berlin, Germany50 enrolled1 locationNCT07529197
Recruiting
Phase 1

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmSymptomatic COVID-19 Infection Laboratory-Confirmed+4 more
M.D. Anderson Cancer Center30 enrolled1 locationNCT05101213
Recruiting
Phase 2

Arginine Replacement Therapy in COVID-19

COVID-19
Emory University21 enrolled1 locationNCT05855330
Recruiting
Phase 1Phase 2

Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmCOVID-19 Infection+2 more
M.D. Anderson Cancer Center70 enrolled1 locationNCT04565665
Recruiting
Not Applicable

Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19

Long COVID-19 Syndrome
Fundación Cardioinfantil Instituto de Cardiología374 enrolled1 locationNCT06871293
Recruiting

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

COVID-19Influenza
National Institute of Allergy and Infectious Diseases (NIAID)150 enrolled1 locationNCT04794829
Recruiting

Immunogenicity of COVID-19 Vaccines in Tuberculosis Patients

TuberculosisCovid-19 Pandemics
University of Oxford133 enrolled1 locationNCT05571735
Recruiting

Respiratory Virus Sampling and Repository

COVID-19Influenza
National Institute of Allergy and Infectious Diseases (NIAID)20,000 enrolled2 locationsNCT05266222
Recruiting
Not Applicable

Long COVID Brain Fog: Cognitive Rehabilitation Trial

Cognitive ImpairmentCognitive DysfunctionPost-Acute COVID-19 Syndrome+2 more
University of Alabama at Birmingham30 enrolled1 locationNCT06095297
Recruiting
Phase 2

Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)

Post COVID-19 ConditionLong COVIDLong COVID Syndrome+2 more
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia90 enrolled1 locationNCT06766825