RecruitingNot ApplicableNCT05051059

Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients


Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

60 participants

Start Date

Oct 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Primary bone and soft tissue sarcomas are an exceptionally rare form of cancer, collectively accounting for only 1% of all malignancies diagnosed. Sarcomas often occur in the patients' extremities and treatment typically involves limb salvage surgery with bone and/or muscle resection. These surgeries often leave the patients with disfigurements, psychological trauma, and functional disabilities. Perhaps, the most difficult and life-altering decision that patients (and their parents) with primary bone sarcomas about the knee joint have to make, involves choosing the type of surgical procedure that will provide them with the outcome that meets their functional as well as aesthetic expectations. In literature, the quality of life for patients with osteosarcoma around the knee joint after three different surgical procedures, that is, amputation, endoprosthetic reconstruction and rotationplasty was evaluated. There was found that patients treated with rotationplasty showed significantly higher functional scores compared to the two other groups of patients. Also, researchers investigated the long-term quality of life after bone sarcoma surgery around the knee joint and found that, despite the functional disability, survivors were busy with work, study, relationships, and sometimes they have founded a family. Most published reports in the literature on assessment of gait in the lower-extremity sarcoma survivors were focused on bone sarcoma patients after wide resection and endoprosthetic reconstruction. To the knowledge of the investigator, there has been no published studies on gait analysis after resection of soft tissue sarcomas (STS) of the lower extremity. The rare and heterogeneous aspects of STS and the paucity of knowledge of movement strategies in these patients hinder the development of effective rehabilitation protocols for recovering movement after resection of STS in the lower limb.


Eligibility

Min Age: 18 YearsMax Age: 95 Years

Inclusion Criteria4

  • Patients who underwent limb salvage surgery for bone or soft tissue sarcoma of the lower extremity at UZ Leuven
  • to 95 years old
  • Patients should be at least one year post surgery
  • Informed consent has obtained

Exclusion Criteria3

  • Patients who received major prior surgery of the lower limbs or with any pathology, injury or disorder known to affect the locomotor system
  • Skeletally immature individuals
  • No informed consent has obtained

Interventions

OTHERFunctional outcome

3D-motion analysis and strength assessment

OTHERHealth related quality of life (HRQoL) assessment

Quality of Life Questionnaire C-30 (QLQ-C30), Impact on Participation and Autonomy Questionnaire (IPAQ) and Musculoskeletal Tumor Society Score (MSTS)


Locations(1)

UZ Leuven

Leuven, Vlaams-Brabant, Belgium

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NCT05051059


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