Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

This early-phase study is testing a personalized RNA vaccine made from a patient's own tumor — combined with an anti-PD-1 immunotherapy drug — to see if it can help the immune system better fight cancer. Each vaccine is custom-made using genetic material extracted from the patient's own tumor cells. **You may be eligible if...** - You are 18 years or older - You are in generally good health (ECOG 0–2) - You have a solid tumor that can be surgically sampled to extract RNA - You have only one active cancer at the time of enrollment - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your tumor cannot be safely sampled for RNA extraction - You have active autoimmune disease requiring treatment - You have recently received chemotherapy, immunotherapy, or radiation therapy (within defined washout periods) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.