RecruitingNot ApplicableNCT05051254

Respiratory Muscles and Work of Breathing in Children


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

550 participants

Start Date

Jan 19, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management. The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.


Eligibility

Min Age: 0 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study measures how hard children with respiratory muscle problems have to work to breathe. Researchers at Necker Hospital study children who breathe on their own or with ventilator support to better understand their breathing mechanics and improve care. You may be eligible if: - Your child is under 18 years old - Your child has been diagnosed with primary or secondary respiratory muscle impairment and is followed at Necker Hospital - Your child breathes spontaneously or uses non-invasive or invasive mechanical ventilation - Written informed consent has been obtained You may NOT be eligible if: - Your child does not have social insurance coverage - Your child has significant cognitive or motor developmental delays that would prevent cooperation - Your child is severely agitated or hemodynamically unstable - Your child has an acute illness or is on medications that could interfere with the breathing measurements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEREsogastric pressure measurement

Measurement of work of breathing and respiratory muscles strength using an esogastric catheter. One measurement or before and after (6 months and 1 year) the initiation of a pharmacological treatment in order to assess the effect of the treatment on respiratory muscle function.


Locations(1)

Hôpital Necker-Enfants Malades

Paris, France

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NCT05051254


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