RecruitingNot ApplicableNCT05051254

Respiratory Muscles and Work of Breathing in Children


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

550 participants

Start Date

Jan 19, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management. The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.


Eligibility

Min Age: 0 YearsMax Age: 17 Years

Inclusion Criteria3

  • Patients aged less than 18 years old with primary or secondary impairment of respiratory muscles and followed at Necker Hospital
  • Patients under spontaneous breathing or noninvasive or invasive mechanical ventilation
  • Written informed consent

Exclusion Criteria6

  • No social insurance
  • Significant psychomotor retardation
  • Absence of cooperation
  • Significant agitation
  • Hemodynamic instability
  • Acute condition or temporary drug treatments that may interfere with the results of the respiratory muscle explorations

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Interventions

OTHEREsogastric pressure measurement

Measurement of work of breathing and respiratory muscles strength using an esogastric catheter. One measurement or before and after (6 months and 1 year) the initiation of a pharmacological treatment in order to assess the effect of the treatment on respiratory muscle function.


Locations(1)

Hôpital Necker-Enfants Malades

Paris, France

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NCT05051254


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