RecruitingPhase 2NCT05052853

Early Intervention of Prodromal Schizophrenia Using an NMDA Enhancer


Sponsor

China Medical University Hospital

Enrollment

48 participants

Start Date

Nov 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Previous studies found that some NMDA-enhancing agents were able to improve clinical symptoms of patients with schizophrenia. Whether treatment of an NMDA-enhancing agent can benefit the treatment of prodromal schizophrenia deserves study.


Eligibility

Min Age: 13 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a drug that boosts a brain chemical (NMDA receptor enhancer) can reduce early warning signs of schizophrenia — a phase called "prodromal schizophrenia" or "clinical high risk" — and potentially prevent or delay the onset of full psychosis. **You may be eligible if...** - You have early or mild symptoms suggesting a risk of developing schizophrenia (attenuated psychotic symptoms, brief psychotic episodes, or a family history with recent functioning decline) - You remain symptomatic after a 6-week health support program - You are either not on psychiatric medication, or have been on stable doses for at least 4 weeks **You may NOT be eligible if...** - You have already experienced a full psychotic episode requiring hospitalization - You have serious physical health problems that interact with the study drug - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNMDAE

Use of an NMDA enhancer for the treatment of prodromal schizophrenia .

DRUGPlacebo Cap

Use of placebo as a comparator


Locations(1)

Department of Psychiatry, China Medical University Hospital

Taichung, Taiwan

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NCT05052853


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