PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy

This study compares proton therapy versus conventional photon (X-ray) radiation in people with esophageal cancer who are being treated with chemotherapy plus radiation before surgery. Both are types of radiation; proton therapy is more targeted and may reduce side effects to the heart and lungs. **You may be eligible if...** - You are 18 or older with histologically confirmed esophageal or gastroesophageal junction cancer (squamous cell or adenocarcinoma) - Your cancer has not spread to distant organs (M0) - You are being considered for curative treatment (chemotherapy + radiation followed by surgery) - Your blood counts, liver, and kidney function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread to distant organs (M1) - You are not able to tolerate surgery or the combined treatment approach - Your blood counts or organ function are too low - You are pregnant Talk to your doctor to see if this trial is right for you.