Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis

This study tests a combination approach for colorectal cancer that has spread to the liver, after other treatments have stopped working. The approach combines freezing the tumor (cryoablation) with two drugs: sintilimab (an immunotherapy) and regorafenib (a targeted therapy). **You may be eligible if...** - You have colorectal cancer that has spread to the liver - You have already tried at least two different chemotherapy regimens that stopped working - You are 18 or older and have reasonable overall health and organ function - You have at least one measurable tumor on imaging **You may NOT be eligible if...** - You have had previous cryoablation or regorafenib treatment - You had major surgery, radiation, or other liver procedures within the last 4 weeks - You have HIV, an active autoimmune disease, or require ongoing immunosuppressants - You have a history of stroke, blood clots, or significant heart disease in the past 6 months - You have a second active cancer Talk to your doctor to see if this trial is right for you.