RecruitingNot ApplicableNCT05064540

JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization


Sponsor

Endologix

Enrollment

450 participants

Start Date

Sep 20, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Prospective, randomized, multi-center study designed to evaluate the outcomes of commercially available contemporary EVAR in a real-world population. Patients will be randomized into two device cohorts and compared across the primary endpoints. Patients will be followed procedurally to discharge, at 1, 6, 12 months and annually through to 5 years (total follow-up commitment).


Eligibility

Min Age: 21 Years

Inclusion Criteria5

  • Adult age 21 and older
  • Subjects with minimum of 2 year life expectancy
  • Subjects have signed the informed consent document
  • Subjects with unruptured infrarenal AAA who are assessed by the Investigator to be eligible for endovascular Abdominal Aortic Aneurysm Repair with the trial devices.
  • Patient must be able and willing to comply with all required follow-up exams.

Exclusion Criteria7

  • Currently participating in another trial where the primary endpoint has not been reached yet.
  • Known allergy to any of the device components
  • Pregnant (females of childbearing potential only)
  • Known connective tissue disorders
  • Known active infection
  • Subjects with pre-existing EVAR, i.e., in need of repair/intervention of a previously failed EVAR.
  • Patient has other medical, social, or psychological conditions that, in the opinion of the investigator, preclude them from receiving the pre-treatment, required treatment, and post-treatment procedures and evaluations.

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Interventions

DEVICEAlto Abdominal Stent Graft System

Endovascular Abdominal Aneurysm Repair (EVAR) using commercially available, FDA approved endovascular graft systems implanted.

DEVICEFDA Approved EVAR AAA Graft Systems

FDA approved comparator of choice


Locations(29)

Huntsville Hospital

Huntsville, Alabama, United States

University of Arizona

Tucson, Arizona, United States

Washington Regional Medical Center

Fayetteville, Arkansas, United States

Central Arkansas Veterans Healthcare System

Little Rock, Arkansas, United States

The Regents of the University of California, San Diego

La Jolla, California, United States

Veterans Affairs San Diego Healthcare System

San Diego, California, United States

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Radiology and Imaging Specialists

Lakeland, Florida, United States

Baptist Hospital of Miami, Miami Cardiac and Vascular Institute

Miami, Florida, United States

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

University of Louisville

Louisville, Kentucky, United States

Tufts Medical Center

Boston, Massachusetts, United States

Henry Ford Hospital

Detroit, Michigan, United States

University of Missouri

Columbia, Missouri, United States

Newark Beth Israel Medical Center

Newark, New Jersey, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Feinstein Institutes for Medical Research (Staten Island University Hospital/Northwell Health)

Staten Island, New York, United States

The Cleveland Clinical Foundation

Cleveland, Ohio, United States

The Ohio State University

Columbus, Ohio, United States

Oregon Health Sciences University

Portland, Oregon, United States

U.S. Department of Veterans Affairs, VA Portland Health Care System

Portland, Oregon, United States

Lehigh Valley Health Network

Allentown, Pennsylvania, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Allegheny Health Network

Pittsburgh, Pennsylvania, United States

Wellmont Cardiology Services

Kingsport, Tennessee, United States

The University of Texas Medical Branch at Galveston

Galveston, Texas, United States

Houston Methodist Research Institute

Houston, Texas, United States

Sentara Hospitals

Norfolk, Virginia, United States

View Full Details on ClinicalTrials.gov

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NCT05064540


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