RecruitingNot ApplicableNCT07171190

Targeted Abdominal CT in Conjunction With Lung Cancer Screening

Targeted Abdominal CT in Conjunction With Lung Cancer Screening - a Pilot Study (TACTICAL1): a Randomised Controlled Pilot Study of Adding Abdominal Non-contrast CT to Lung Cancer Screening CT Thorax Amongst High Lung Cancer Risk Ever-smokers Aged 55-70.


Sponsor

University of Cambridge

Enrollment

6,272 participants

Start Date

Nov 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked. Those at higher risk of lung cancer are offered a lung scan. This group also has a high risk of developing abdominal cancers, such as kidney cancer. A recent study explored whether it would be feasible to extend the lung scan to include the abdomen. Results showed most participants supported this addition, and the number of serious findings was similar to those detected in UK breast or bowel cancer screening programmes. However, the abdominal scan was only offered on the day of the lung scan, giving little time for people to consider their decision. The process also added too much time to be practical for widespread implementation. This new study will: * Test whether mentioning the possible abdominal scan in the initial LCS invitation affects participation in LCS assessments. * Test new processes to assess if the abdominal scan can be added to the lung scan with minimal extra time. * Check if participants can be split between the lung scan only group and lung and abdominal scan group using an approach called 'cluster randomisation'. This will be important in case a bigger trial is needed. * See whether the additional processes are acceptable People aged 55-70 who are invited to the lung cancer screening will be eligible to take part in this study. Only those who are found to be at a high risk of lung cancer after their assessment, and therefore offered a lung scan, will be offered the abdominal scan, provided they have not had an abdominal scan in the previous 12 months or one booked in the next 3 months. This study will take place in two existing lung cancer screening locations in Yorkshire.


Eligibility

Min Age: 55 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether offering an additional abdominal CT scan alongside lung cancer screening (for those who qualify for a low-dose chest CT) helps detect abdominal cancers and other conditions earlier in smokers and ex-smokers. You may be eligible if: you are between 55 and 70 years old; you are a current or former smoker registered in a lung cancer screening program in West Yorkshire or Humber/North Yorkshire, England; and you are registered with a GP in England. You may NOT be eligible if: you have already had an abdominal CT in the past 12 months or have one booked in the next 3 months; your weight exceeds scanner limits; you cannot lie flat; or you are too unwell for treatment. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLung Cancer Screening Invitation Intervention

Participants are invited to the NHS Lung Cancer Screening to assess lung cancer risk via letter or text message

DIAGNOSTIC_TESTAbdominal scan intervention

Receiving an abdominal CT scan at the same time as the lung scan.


Locations(1)

Hull Teaching Hospitals Trust

Hull, United Kingdom

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NCT07171190


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