RecruitingNot ApplicableNCT05065840

Advancing HPV Vaccination Among HIV Positive Adults: The CHAMPS Study

Implementing an Evidence-Based, Multilevel Intervention to Promote HPV Vaccination Among HIV Positive Adults

Sponsor

Emory University

Enrollment

365 participants

Start Date

May 22, 2023

Study Type

INTERVENTIONAL

Conditions

Human Papilloma Virus Human Papilloma Virus Vaccine

Summary

People living with HIV (PLWH) are 28 times more likely to be diagnosed with Human Papillomavirus (HPV) - associated anal cancer than the general population. The HPV vaccine is an effective and safe approach to prevent and reduce the risk of HPV-related disease among PLWH. HPV vaccine programs tailored and implemented in the HIV population are lagging for this high-risk group. The CDC's 4 Pillars Transformation Program is a multi-level, evidence-based intervention that has been successfully used to increase HPV vaccination in the general population and is ready to be tested in the high-risk HIV population, particularly PLWH in the rural South. This program offers providers and clinic staff evidence-based strategies to increase HPV vaccination uptake via training and educational resources. This study proposes to tailor and refine the 4 Pillars Program and conduct this project in three HIV clinics in Georgia.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study (CHAMPS) tests interventions to improve HPV vaccination rates among HIV-positive adults. HPV (human papillomavirus) causes several cancers, and people living with HIV are at higher risk. The study tests messaging and support strategies to increase completion of the HPV vaccine series. **You may be eligible if...** - You are HIV-positive and aged 18–45 - You can read and speak English - You have not yet completed a full 3-dose HPV vaccine series - You have no contraindications to the HPV vaccine (e.g., no severe latex allergy or yeast allergy, not severely ill, not pregnant) **You may NOT be eligible if...** - You have already completed all 3 HPV vaccine doses - You have a contraindication to the HPV vaccine (severe allergy to latex or yeast, active moderate/severe illness, or pregnancy) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCDC 4 Pillars Program

The CDC's 4 Pillars Transformation Program (4 Pillars Program) is a robust and empirically supported strategic approach that promotes the uptake of adult vaccinations and addresses facilitators and barriers at the patient, provider, and clinic level. This multi-level, evidence-based intervention has been successfully utilized to increase HPV vaccination in the general population and is primed to be tested in the high-risk HIV population, particularly PLWH in the rural South. This proposal seeks to expand the success of the 4 Pillars Program and tailor, refine, and implement in the HIV positive population who are at extraordinarily high risk for HPV-related cancers and can obtain the most benefit from the vaccine.