Cannabidiol for Reduction of Brain Neuroinflammation

This study investigates whether cannabidiol (CBD) can reduce brain inflammation (neuroinflammation) in people with chronic low back pain. Researchers use brain imaging (PET scan) to measure inflammation levels before and after CBD treatment to understand if it has a real biological effect. **You may be eligible if...** - You are aged 18–75 with chronic low back pain ongoing for at least 6 months - Your average pain is at least 4 out of 10 on most days - You are on a stable pain treatment for at least 4 weeks - You carry a specific genetic variant (TSPO polymorphism) that allows accurate PET brain imaging — this is checked with a blood test **You may NOT be eligible if...** - You have had surgery within the past 1–2 months, or have not fully recovered - You have elevated liver enzyme levels - You have had interventional pain procedures (e.g., injections) within 6 weeks or plan them during the study - You have contraindications to PET/CT scanning Talk to your doctor to see if this trial is right for you.