RecruitingNot ApplicableNCT05426967

rTMS for Military TBI-related Depression

ADEPT: Adaptive Trial for the Treatment of Depressive Symptoms Associated With Concussion Using Repetitive Transcranial Magnetic Stimulation Protocols


Sponsor

Henry M. Jackson Foundation for the Advancement of Military Medicine

Enrollment

198 participants

Start Date

Dec 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a history of concussion/mild traumatic brain injury (TBI).


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique that uses magnetic pulses — as a treatment for depression in military veterans and service members who have a history of mild traumatic brain injury (concussion). **You may be eligible if:** - You are between 18 and 55 years old - You are a current or former U.S. military member eligible for care at a military or VA facility - You have a history of mild TBI (concussion) that occurred between 6 months and 26 years ago - You currently have at least mild-to-moderate depression (MADRS score above 13) - You have been on a stable psychiatric medication regimen for at least 6 weeks - You are under the care of a primary care or behavioral health provider **You may NOT be eligible if:** - You have a history of seizures, metal implants in the head, or other rTMS contraindications - Your depression is severe enough to require hospitalization imminently - You have a history of psychosis or bipolar disorder - You have active substance use disorder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICERepetitive Transcranial Magnetic Stimulation (rTMS)

Active rTMS

DEVICESham rTMS

Sham comparator to active rTMS


Locations(3)

VA Palo Alto Health Care System

Palo Alto, California, United States

William Beaumont Army Medical Center

Fort Bliss, Texas, United States

Alexander T. Augusta Military Medical Center

Fort Belvoir, Virginia, United States

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NCT05426967


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