Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

This trial (called HEADLIGHT) is comparing proton beam therapy to standard X-ray radiation after surgery for head and neck cancer, to see if proton therapy causes fewer side effects while being equally effective. **You may be eligible if...** - You are 18 or older - You have a newly diagnosed, non-HPV-associated head or neck cancer (in the nasal cavity, sinuses, mouth, throat, larynx, or salivary glands) - Your cancer has not spread to other parts of the body (M0 confirmed by PET/CT) - Your general health is good (ECOG 0–1 before initial treatment) - You are willing to return to the study site for follow-up visits **You may NOT be eligible if...** - You have a serious coexisting illness that makes you a poor candidate for this study - Your cancer is HPV-related (except in specific situations) - You are not able to complete questionnaires or follow-up requirements Talk to your doctor to see if this trial is right for you.