Head and Neck Carcinoma Clinical Trials

39 recruitingLast updated: June 17, 2026

There are 39 actively recruiting head and neck carcinoma clinical trials across 8 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include Houston, Texas, United States, Jacksonville, Florida, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Head and Neck Carcinoma Trials at a Glance

39 actively recruiting trials for head and neck carcinoma are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Houston, Jacksonville, and New York. Lead sponsors running head and neck carcinoma studies include Mayo Clinic, M.D. Anderson Cancer Center, and Centre Jean Perrin.

Browse head and neck carcinoma trials by phase

Treatments under study

About Head and Neck Carcinoma Clinical Trials

Looking for clinical trials for Head and Neck Carcinoma? There are currently 26 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Head and Neck Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Head and Neck Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 39 trials

Recruiting

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

Breast CarcinomaEsophageal CarcinomaHead and Neck Carcinoma+6 more
M.D. Anderson Cancer Center5,000 enrolled1 locationNCT00991094
Recruiting
Not Applicable

A Financial Intervention (Financial Compass) to Identify and Address Financial Hardship Among Head and Neck Cancer Patients, Financial Compass Trial

Head and Neck Carcinoma
Roswell Park Cancer Institute50 enrolled1 locationNCT06896695
Recruiting
Phase 2

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Head and Neck CarcinomaHead and Neck CancerOral Cancer+1 more
Case Comprehensive Cancer Center30 enrolled1 locationNCT06627270
Recruiting
Not Applicable

cDNA and Residual Disease After Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinomas

Locally Advanced Head and Neck Carcinoma
Centre Jean Perrin59 enrolled3 locationsNCT07178847
Recruiting

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Head and Neck CarcinomaMalignant Solid NeoplasmSarcoma+59 more
Alliance for Clinical Trials in Oncology2,000 enrolled746 locationsNCT05334069
Recruiting
Not Applicable

Prediction of Residual Disease by Circulating DNA Detection After Potentiated Radiotherapy for Locally Advanced Head and Neck Cancer

Locally Advanced Head and Neck Carcinoma
Centre Jean Perrin63 enrolled4 locationsNCT05710679
Recruiting
Phase 1

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Locally Advanced Head and Neck Squamous Cell CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Hypopharyngeal Carcinoma AJCC v8+23 more
National Cancer Institute (NCI)46 enrolled18 locationsNCT05172245
Recruiting
Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Breast CarcinomaUrothelial CarcinomaOvarian Carcinoma+26 more
Mayo Clinic27 enrolled1 locationNCT07285044
Recruiting
Not Applicable

Geriatric Assessment and Management for Older Adults Undergoing Chemotherapy and Radiation Therapy for Head and Neck Cancer and Their Family Caregivers

Localized Head and Neck Carcinoma
City of Hope Medical Center36 enrolled1 locationNCT07225855
Recruiting

An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

Head and Neck Carcinoma
University of Southern California50 enrolled1 locationNCT06420219
Recruiting
Not Applicable

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

Head and Neck CarcinomaHead and Neck CancerHead and Neck Neoplasms
University of California, San Francisco120 enrolled1 locationNCT07556367
Recruiting
Not Applicable

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

Head and Neck Squamous Cell CarcinomaMetastatic Head and Neck Squamous Cell CarcinomaStage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8+30 more
Emory University118 enrolled1 locationNCT06662058
Recruiting

Oropharynx (OPX) Biomarker Trial

Head and Neck CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+8 more
Mayo Clinic560 enrolled1 locationNCT06356272
Recruiting
Phase 2

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

Carcinoma of Unknown PrimaryMetastatic Malignant Neoplasm in the Uterine CervixClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+28 more
M.D. Anderson Cancer Center471 enrolled1 locationNCT03010150
Recruiting
Phase 2

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

Head and Neck CarcinomaOral Cavity CarcinomaMalignant Parotid Gland Neoplasm+4 more
M.D. Anderson Cancer Center119 enrolled7 locationsNCT04870762
Recruiting
Not Applicable

Cancer Genetic Testing in Ethnic Populations

Breast CarcinomaHead and Neck CarcinomaMalignant Brain Neoplasm+8 more
Mayo Clinic1,800 enrolled2 locationsNCT04475640
Recruiting
Phase 1

Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+2 more
University of Chicago30 enrolled1 locationNCT05526924
Recruiting
Phase 2

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+1 more
Memorial Sloan Kettering Cancer Center12 enrolled6 locationsNCT05544136
Recruiting
Not Applicable

A New Way to Share Radiation Therapy Plans Between Doctors, CORRECT Trial

Head and Neck CarcinomaLung Carcinoma
Wake Forest University Health Sciences194 enrolled1 locationNCT07282444