Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

This study is testing whether low-dose oral ketamine can reduce anxiety in people with pancreatic cancer. Ketamine is a medication more commonly known as an anesthetic, but it is increasingly being studied for mental health conditions. This trial explores whether it can help cancer patients who are feeling severely anxious. **You may be eligible if...** - You have been diagnosed with pancreatic cancer - You are currently receiving or recently completed cancer treatment (surgery, chemo, radiation, or immunotherapy) - You have moderate to severe anxiety based on a questionnaire score - You are 18 or older - You can read and understand English - Your liver function is adequate **You may NOT be eligible if...** - You are pregnant or trying to become pregnant - You have a history of psychosis or certain psychiatric conditions that could be worsened by ketamine - You have a history of substance abuse involving ketamine or related drugs - You drive or operate heavy machinery and are unwilling to avoid these activities after taking doses - You have poor liver function Talk to your doctor to see if this trial is right for you.