Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
260 participants
Jun 30, 2021
INTERVENTIONAL
Conditions
Summary
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
Eligibility
Inclusion Criteria6
- Age 65-85 years
- Gender: Men or Women
- MOCA \> 26
- Independently living and able to drive
- OSA (AHI ≥ 15/h) or no OSA
- Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas)
Exclusion Criteria11
- Currently smoking
- History of COPD or asthma
- Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension
- Neuromuscular Disease
- Drowsy Driving (ESS \> 18/24)
- Inability to complete study procedures, such as questionnaire that are only available/validated in English
- Lack of decisional capacity to provide informed consent
- Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
- Presence of a brain tumor or lobar stroke
- Current drug or alcohol abuse/dependence
- Prisoners
Interventions
Subjects will be instrumented with a nasal cannula to receive 2L/min supplemental oxygen. The oxygen will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.
Continuous positive airway pressure is a form of positive airway pressure ventilation in which a constant level of pressure greater than atmospheric pressure is continuously applied to the upper respiratory tract of a person.
Subjects will be instrumented with a nasal cannula to receive 2L/min pressurized room air. The room air will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05094271