Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

This study is investigating whether obstructive sleep apnea (OSA) — a condition where breathing repeatedly stops during sleep — contributes to the development of Alzheimer's disease in older adults. Researchers will use brain scans and other tests to look for early signs of Alzheimer's in people with and without sleep apnea. **You may be eligible if...** - You are between 65 and 85 years old - You have normal or near-normal thinking and memory (MoCA score > 26) - You live independently and are able to drive - You either have been diagnosed with sleep apnea (AHI ≥ 15/hour) or confirmed to not have it - You are willing to waive access to your Polygenic Health Score (a genetic risk score) during the study **You may NOT be eligible if...** - You currently smoke - You have COPD, asthma, Class III/IV heart failure, or uncontrolled high blood pressure - You have a neurological condition that affects muscle control - You feel excessively sleepy while driving (ESS score > 18) - You cannot have an MRI (e.g., pacemaker, metal implants) - You have a history of brain tumor or major stroke - You have a current drug or alcohol problem Talk to your doctor to see if this trial is right for you.