Hypofractionated vs Conventional Fractionated RT in Soft Tissue Sarcomas

This study is comparing two radiation schedules before surgery for people with soft tissue sarcoma (a cancer of connective tissues like muscle or fat): a shorter, more concentrated dose versus a longer, conventional course of radiation. **You may be eligible if...** - You have biopsy-confirmed soft tissue sarcoma of the arm, leg, trunk, or head and neck - You have not previously received chemotherapy or radiation for this sarcoma - You are 18 years or older and in reasonably good health (Karnofsky score ≥60%) - Your tumor is operable and you are medically fit for surgery - Surgery can be planned within 5–14 days after completing radiation **You may NOT be eligible if...** - You have previously received radiation or chemotherapy for your sarcoma - Your tumor cannot be surgically removed - Your general health is too poor to safely undergo surgery - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.