RecruitingNCT05116943

Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

Sponsor

Mayo Clinic

Enrollment

100 participants

Start Date

Aug 19, 2013

Study Type

OBSERVATIONAL

Conditions

Amyotrophic Lateral Sclerosis

Summary

The purpose of this study is to collect CSF and blood samples that can be used in future research studies to identify potential biomarkers in blood and cerebrospinal fluid (CSF) collected in Amyotrophic Lateral Sclerosis (ALS) patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Clinical diagnosis of possible, laboratory-supported probable, probable or definite ALS according to modified eL Escorial criteria, suspected ALS according to original el Escorial criteria, or diagnosis of a similar neurodegenerative disorder.
Willing to provide consent, or assent, if physically unable to consent owing to disease-related muscle weakness.
No personal history of ALS, ALS-FTD or other motor neuron disease.
Subjects with family history of ALS, ALS-FTD the affected family member needs to be a first, second, or third degree blood relative.
Willing to provide consent.

Exclusion Criteria5

History of medical disorder that leaves in question whether neurological signs and symptoms potentially related to a neurodegenerative disease may be caused by another unrelated disorder.
Limited mental capacity rendering the subject unable to comply with lumbar puncture or standard phlebotomy procedures.
For lumbar puncture, an increased risk of bleeding complications or allergy to local anesthetic administered or skin antiseptic used for lumbar puncture.
Limited mental capacity rendering the subject unable to comply with lumbar puncture or standard phlebotomy procedures.
For lumbar puncture, an increased risk of bleeding complications or allergy to local anesthetic administered or skin antiseptic used for lumbar puncture.

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