RecruitingNot ApplicableNCT05120635

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans


Sponsor

Duke University

Enrollment

80 participants

Start Date

Oct 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This research study is measuring electrical brain activity related to fear and anxiety in people who already have brain electrodes implanted for epilepsy treatment. Researchers are using those existing electrodes to record brain signals during fear-related tasks to better understand the brain regions involved in anxiety. This knowledge could help develop better treatments for anxiety disorders. **You may be eligible if...** - You are 18 or older - You have already had depth electrodes or a responsive neurostimulation (RNS) device placed in your brain for epilepsy - You are willing and able to participate and give informed consent - You are able to read and write English fluently **You may NOT be eligible if...** - You have not had brain electrodes implanted - You are pregnant - You have active psychosis - You have current suicidal thoughts - You have an active substance abuse problem Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDeep Brain Stimulation

Deep brain stimulation will be used

BEHAVIORALVirtual and augmented reality tasks

Virtual and augmented reality tasks will be used.


Locations(2)

University of California Los Angeles

Los Angeles, California, United States

Duke University Health System

Durham, North Carolina, United States

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NCT05120635


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