DETERMINE: Detemir vs NPH

This trial (DETERMINE) is comparing two types of long-acting insulin — insulin detemir (a newer insulin analog) and NPH insulin (an older standard) — for managing blood sugar during pregnancy in women who have type 2 diabetes or gestational diabetes (diabetes that develops during pregnancy) and need insulin. The goal is to find out which insulin is safer and more effective for mother and baby. **You may be eligible if...** - You are a pregnant woman aged 18 or older - You have pre-existing type 2 diabetes or gestational diabetes that requires insulin to control blood sugar during pregnancy - You do not have type 1 diabetes **You may NOT be eligible if...** - You are carrying multiple babies (twins, triplets, etc.) - You have type 1 diabetes - You have known allergy to NPH insulin or insulin detemir - You have chronic kidney or liver disease - You are HIV positive or have Hepatitis B or C - You have a known major fetal abnormality or are scheduled for premature delivery - You were already on insulin before you became pregnant Talk to your doctor to see if this trial is right for you.