RecruitingNCT05129605

Prostate Cancer Genetic Risk Evaluation and Screening Study

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)


Sponsor

Massachusetts General Hospital

Enrollment

400 participants

Start Date

Feb 12, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations, family history, or Black/African ancestry and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population of men are at elevated risk of developing prostate cancer compared to the general population, and enhanced screening with MRI will enable early detection and diagnosis of potentially aggressive prostate cancer, characterization of the penetrance of specific mutations, and potentially identify new genetic risk mutations.


Eligibility

Sex: MALEMin Age: 35 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This study screens men at higher-than-average genetic risk for prostate cancer to catch it early. It focuses on men with inherited gene mutations, strong family history, or who identify as Black American or Black Caribbean (groups with higher prostate cancer risk). **You may be eligible if...** - You are a man between 35 and 74 years old - You have NOT been diagnosed with prostate cancer - You have a life expectancy of more than 10 years - You have a known genetic mutation linked to prostate cancer risk (such as BRCA2, ATM, CHEK2, etc.), OR a strong family history of prostate cancer, OR you self-identify as Black American or Black Caribbean **You may NOT be eligible if...** - You already have a prostate cancer diagnosis - You are outside the 35–74 age range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTProstate cancer screening

Physical exam (digital rectal exam), prostate-specific antigen (PSA) and PSA derivatives, and multiparametric MRI of the prostate


Locations(1)

Massachusetts General Hospital

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05129605


Related Trials