A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia
A Single-blinded Randomized-controlled Study to Reduce Persistent Post-mastectomy Pain Using Multimodal Opioid-free Anesthesia
Gangnam Severance Hospital
230 participants
Dec 16, 2021
INTERVENTIONAL
Conditions
Summary
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.
Eligibility
Inclusion Criteria1
- All of patients will undergo mastectomy with or without immediate breast reconstruction.
Exclusion Criteria10
- Previous history of breast surgery
- Allergy to drug
- Other cancer history
- Underlying psychologic disorder
- Patients with chronic pain requiring pain killers
- Baseline SpO2 \<95%
- Left ventricular EF \<40%
- Bradycardia as HR \<50 bpm
- BMI \>35kg/m2
- Pregnant woman
Interventions
OFA group will be sedated using dexmedetomidine and lidocaine.
Conventional opioid-based anesthesia group will be sedated using remi-fentanyl
Locations(1)
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NCT05146778