RecruitingNCT05155267

Biomonitoring of Internal Exposure to MNPLs, and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)

Biomonitoring of Internal Exposure to MNPLs (Micro and NanoPlastics), and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)


Sponsor

Ricard Marcos

Enrollment

50 participants

Start Date

Feb 27, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Micro and nanoplastics (MNPLs) effects on human heath is still preliminary. Chronic kidney disease (CKD) participants, specially does patients submitted to hemodialysis, are a population high exposed to plastics. The objective of our research is to be able to detect MNPLs on biological fluids of hemodialysis patients as well as their potential genotoxic and immunological damage.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria17

  • Participant submitted to hemodialysis for more than 3 months
  • Between 18 and 85 years old
  • Stable haemoglobin (more than 10 gr/dl)
  • Absence of infectious disease at the date of sample collection and for a period of more than two weeks
  • Absence of active neoplasia
  • Stable vascular access
  • No hemodialysis treatment
  • Between 18 and 85 years old
  • Stable haemoglobin (more than 10 gr/dl)
  • Glomerular filtration ≤ 20 ml/min
  • Absence of infectious disease at the date of sample collection and for a period of more than two weeks
  • Absence of active neoplasia
  • Between 18 and 85 years old (paired by gender, age and lifestyle to the CKD patients)
  • Absence of chronic kidney disease or dialysis treatment
  • Absence of chronic pathology (including neoplasia)
  • Absence of infectious disease at the date of sample collection and for a period of more than two weeks
  • Spanish residence

Exclusion Criteria9

  • Clinical instability
  • Life expectancy of less than 12 months
  • Coagulation system disorders
  • Participation in other clinical study
  • Pregnancy
  • Unsigned informed consent
  • Participation in other clinical study
  • Pregnancy
  • Unsigned informed consent

Interventions

OTHERBiomonitoring study to detect MNPLs in biological samples and study of their health effects

Determination of MNPLs levels, genotoxic damage and immunological effects


Locations(1)

Servicio Murciano de Salud

Murcia, Spain

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NCT05155267


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