Biomonitoring of Internal Exposure to MNPLs, and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)
Biomonitoring of Internal Exposure to MNPLs (Micro and NanoPlastics), and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)
Ricard Marcos
50 participants
Feb 27, 2024
OBSERVATIONAL
Conditions
Summary
Micro and nanoplastics (MNPLs) effects on human heath is still preliminary. Chronic kidney disease (CKD) participants, specially does patients submitted to hemodialysis, are a population high exposed to plastics. The objective of our research is to be able to detect MNPLs on biological fluids of hemodialysis patients as well as their potential genotoxic and immunological damage.
Eligibility
Inclusion Criteria17
- Participant submitted to hemodialysis for more than 3 months
- Between 18 and 85 years old
- Stable haemoglobin (more than 10 gr/dl)
- Absence of infectious disease at the date of sample collection and for a period of more than two weeks
- Absence of active neoplasia
- Stable vascular access
- No hemodialysis treatment
- Between 18 and 85 years old
- Stable haemoglobin (more than 10 gr/dl)
- Glomerular filtration ≤ 20 ml/min
- Absence of infectious disease at the date of sample collection and for a period of more than two weeks
- Absence of active neoplasia
- Between 18 and 85 years old (paired by gender, age and lifestyle to the CKD patients)
- Absence of chronic kidney disease or dialysis treatment
- Absence of chronic pathology (including neoplasia)
- Absence of infectious disease at the date of sample collection and for a period of more than two weeks
- Spanish residence
Exclusion Criteria9
- Clinical instability
- Life expectancy of less than 12 months
- Coagulation system disorders
- Participation in other clinical study
- Pregnancy
- Unsigned informed consent
- Participation in other clinical study
- Pregnancy
- Unsigned informed consent
Interventions
Determination of MNPLs levels, genotoxic damage and immunological effects
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05155267