RecruitingPhase 2NCT05159245

The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs

The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs to Determine the Efficacy in Treatment of Advanced Cancers With a Known Molecular Profile


Sponsor

Helsinki University Central Hospital

Enrollment

250 participants

Start Date

Dec 10, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective non-randomized national clinical phase 2 trial that aims to determine the efficacy and toxicity of targeted anticancer drugs or combinations that are approved or under review by EMA, FDA or PMDA and are used for treatment of patients with advanced cancer with a potentially actionable variant as revealed by a genomic, RNA-molecular or protein expression test.


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Abemaciclib, a drug called Alectinib, and others for people with advanced cancer, haematological malignancy, and other related conditions. The study is currently recruiting participants at 5 locations. People eligible for this study include aged 18 Years to 100 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAlectinib

ALK

DRUGCobimetinib

MEK1, MEK2

DRUGVismodegib

Hedgehog

DRUGTrastuzumab+Pertuzumab

HER2

DRUGEntrectinib

NTRK/ ROS1, ALK

DRUGAtezolizumab

PD-L1

DRUGVemurafenib

BRAF V600

DRUGRegorafenib

KIT/BRAF, RET

DRUGApalutamide

AR

DRUGAbemaciclib

CDK4/6

DRUGTepotinib

MET ex14

DRUGDabrafenib

RAF

DRUGTrametinib

MEK1, MEK2

DRUGDabrafenib+Trametinib

RAF, MEK1, MEK2

DRUGPemigatinib

FGFR2


Locations(5)

Turku University Hospital Cancer Centre

Turku, Southwest Finland, Finland

Helsinki University Hospital Comprehensive Cancer Center

Helsinki, Uusimaa, Finland

Kuopio University Hospital

Kuopio, Finland

Oulu University Hospital OYS Cancer Center

Oulu, Finland

Tampere University Hospital Department of Oncology

Tampere, Finland

View Full Details on ClinicalTrials.gov

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NCT05159245


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