Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder

This study is refining how deep brain stimulation (DBS) — a procedure where a small device is implanted in the brain to send electrical signals — is targeted and optimized for people with severe, treatment-resistant obsessive-compulsive disorder (OCD). **You may be eligible if...** - You are 18 years of age or older - You have severe OCD that has not improved despite many years of treatment - You have already failed at least three different SSRI antidepressants (e.g., fluoxetine, sertraline), clomipramine, combination medication approaches, and an adequate trial of Cognitive Behavioral Therapy (CBT) - You have already decided (with your treating doctor) to receive DBS surgery for OCD outside of this research study **You may NOT be eligible if...** - You do not meet the FDA humanitarian device criteria for DBS in OCD - You have not tried the required number of medications and therapies first - You have not had at least 5 years of severely disabling OCD Talk to your doctor to see if this trial is right for you.