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RecruitingNCT05164744

Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors

Cardiac Magnetic Resonance for Tissue Characterization-Based Risk Stratification of Cardiopulmonary Symptoms, Effort Tolerance, and Prognosis Among COVID-19 Survivors

Sponsor

Weill Medical College of Cornell University

Enrollment

510 participants

Start Date

Jul 1, 2021

Study Type

OBSERVATIONAL

Summary

The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in COVID-19 survivors. If successful, the research will allow us to identify the causes of lasting cardiopulmonary symptoms and begin developing cardiac and lung directed therapies accordingly.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Emergency room presentation and/or hospitalization with COVID-19 infection defined in accordance with established criteria as follows: SAR-CoV2 RT-PCR+ (severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction) and at least one of the following symptoms: dyspnea, cough, dysphagia, rhinorrhea, diarrhea, nausea/vomiting, myalgias, fever, syncope/presyncope.

Exclusion Criteria5

  • Contraindication to CMR (i.e. non-compatible pacemaker/defibrillator) or gadolinium (known hypersensitivity, eGFR (estimated globular filtration rate) <30 ml/min/1.73m2).
  • Inability to provide informed consent (e.g. cognitive impairment).
  • Unrelated condition (e.g. neoplasm) with life expectancy <12 months prohibiting follow-up.
  • Patients with contraindications to gadolinium (known or suspected hypersensitivity, glomerular filtration rate < 30 ml/min/1.73m2) will undergo non-contrast MRI but will not be excluded from this study.
  • Patients with known or suspected pregnancy based on Weill Cornell Radiology intake surveys (reviewed by a clinical RN (registered nurse), as well as research personnel) will be excluded from the protocol.

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Interventions

DIAGNOSTIC_TESTCardiac MRI

Patients participate in an NIH funded cardiac MRI to assess their symptoms.

DIAGNOSTIC_TESTEchocardiogram

Patients participate in an NIH funded cardiac echocardiogram to assess their symptoms.

DIAGNOSTIC_TEST6-minute walk test

Patients participate in a 6-minute walk test to assess their symptoms.

DIAGNOSTIC_TESTQuestionnaire

Patients answer a survey-based questionnaire to assess their symptoms.

Locations(3)

New York Presbyterian-Brooklyn Methodist Hospital

Brooklyn, New York, United States

New York Presbyterian Queens

New York, New York, United States

Weill Cornell Medicine/New-York Presbyterian Hospital

New York, New York, United States

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NCT05164744