Spinal Cord Stimulation for Parkinsonism
Spinal Cord Stimulation for Parkinsonism: a Single-center, Single-arm Open Trial
Ruijin Hospital
50 participants
May 1, 2021
INTERVENTIONAL
Conditions
Summary
Spinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for PDS with SCS. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of orthostatic hypotension, urinary retention, sleep disturbance, dysarthria, and dysphagia in Parkinsonism (PDS) patients before and after SCS treatment, and shed new light on the treatment for PDS.
Eligibility
Inclusion Criteria4
- Diagnosed with parkinsonism according to MDS clinical diagnostic criteria for Parkinson's disease
- Aged between 50 and 80 years
- Able and willing to follow instruction of the researcher
- No other conditions that the researchers consider inappropriate for inclusion
Exclusion Criteria4
- Severe depression (HAMD-17 above 17 as moderate to severe) or anxiety
- Pregnancy
- History of alcoholism
- Non-neurological disease-related symptoms that prevent patients from participation in the study
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Interventions
Spinal cord stimulation (SCS) is a very thin electrode implanted in the dorsal epidural space of the spinal cord to improve the patient's symptoms by stimulating the spinal nerves with pulsed electrical currents, which attenuate or enhance the flow of nerve impulses from the periphery to the central system, i.e., stimulating thick fibers to achieve therapeutic results. SCS system consists of three components: an electrode implanted in the epidural space of the patient's spinal cord, a stimulator implanted subcutaneously in the abdomen or buttocks that delivers electrical impulses, and an extension cord that connects the two.
Locations(1)
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NCT05171205