RecruitingNCT07386015

Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)

FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)

Sponsor

Tianjin Huanhu Hospital

Enrollment

700 participants

Start Date

Feb 28, 2026

Study Type

OBSERVATIONAL

Conditions

Parkinson's Disease Parkinsonism Freezing of Gait Vascular Parkinsonism Idiopathic Normal Pressure Hydrocephalus (INPH)

Summary

This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related neurological conditions.The purpose of this registry is to collect long-term clinical information from patients with freezing of gait or gait and balance problems, and to explore how different causes of FOG are related to symptoms, walking patterns, falls, disease progression, and outcomes over time. The study will include participants with Parkinson's disease and other conditions associated with freezing of gait.Participants will receive standard medical care as determined by their treating physicians. No experimental drugs or study-related treatments will be assigned as part of this registry. Clinical information will be collected during routine visits and follow-up assessments, including questionnaires, walking and balance evaluations, video recordings, and other commonly used clinical tests.The information collected in this study may help improve the understanding of freezing of gait, support better risk assessment for falls, and guide future research and clinical management strategies for patients with gait and balance disorders.

Eligibility

Min Age: 30 YearsMax Age: 85 Years

Inclusion Criteria5

Age 30-85 years
Presence of freezing of gait or non-freezing gait or balance impairment
Diagnosis of Parkinson's disease or related parkinsonian disorders according to established international criteria (including PD, PSP, MSA, DLB, CBD, vascular parkinsonism, or idiopathic normal pressure hydrocephalus)
Ability to complete gait and balance assessment tasks independently or with assistance
Ability and willingness to provide written informed consent

Exclusion Criteria6

Severe dementia (Mini-Mental State Examination score \< 10)
Severe psychiatric disorders interfering with study participation
Severe cardiopulmonary, musculoskeletal, or other medical conditions significantly affecting gait safety
Stroke, fracture, or other major medical events within the past 3 months
Inability to comply with follow-up procedures
Refusal of video or speech data collection

Interventions

OTHERObservational Data Collection

This is an observational patient registry. No experimental drugs, devices, or procedures are assigned as part of the study. All participants receive standard medical care, and data are collected during routine clinical visits and follow-up assessments.