RecruitingNCT07386015

Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)

FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)


Sponsor

Tianjin Huanhu Hospital

Enrollment

700 participants

Start Date

Feb 28, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related neurological conditions.The purpose of this registry is to collect long-term clinical information from patients with freezing of gait or gait and balance problems, and to explore how different causes of FOG are related to symptoms, walking patterns, falls, disease progression, and outcomes over time. The study will include participants with Parkinson's disease and other conditions associated with freezing of gait.Participants will receive standard medical care as determined by their treating physicians. No experimental drugs or study-related treatments will be assigned as part of this registry. Clinical information will be collected during routine visits and follow-up assessments, including questionnaires, walking and balance evaluations, video recordings, and other commonly used clinical tests.The information collected in this study may help improve the understanding of freezing of gait, support better risk assessment for falls, and guide future research and clinical management strategies for patients with gait and balance disorders.


Eligibility

Min Age: 30 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is examining freezing of gait — a sudden inability to start walking or continue walking — in people with Parkinson's disease and related movement disorders. Researchers want to understand the underlying causes and find better ways to predict and treat this disabling symptom. **You may be eligible if...** - You are between 30 and 85 years old - You have a diagnosis of Parkinson's disease or a related condition such as PSP, MSA, DLB, CBD, vascular parkinsonism, or normal pressure hydrocephalus - You experience freezing of gait, other walking difficulties, or balance problems - You can complete gait and balance assessments (with or without assistance) **You may NOT be eligible if...** - You have severe dementia (MMSE score below 10) - You have severe psychiatric problems that would interfere with participation - You have severe heart or lung disease, serious joint problems, or other medical conditions that significantly affect walking safety - You had a stroke, fracture, or major medical event in the last 3 months - You are unwilling to have video or speech recordings taken Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERObservational Data Collection

This is an observational patient registry. No experimental drugs, devices, or procedures are assigned as part of the study. All participants receive standard medical care, and data are collected during routine clinical visits and follow-up assessments.


Locations(1)

Tianjin Huanhu Hospital

Tianjin, Tianjin Municipality, China

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NCT07386015


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