Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
INsIDER: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
University Hospital, Basel, Switzerland
300 participants
Sep 4, 2018
OBSERVATIONAL
Conditions
Summary
This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.
Eligibility
Inclusion Criteria7
- Patients may be diagnosed with:
- active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment.
- non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.
- Age 18-80 years old
- No other neurological or psychiatric disorder
- Age 18-80 years old
- No other neurological or psychiatric disorder
Exclusion Criteria3
- Pregnancy
- Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
- Inability to give consent
Interventions
Each enrolled subject will undergo a MRI at baseline and a second MRI at 2 years (+/- 3 months) follow-up.
Neurocognitive examination for healthy subjects will be performed at both baseline and follow-up
Each enrolled subject will undergo a blood sampling (10 ml) at baseline
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05177523