RecruitingNCT05177523

Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

INsIDER: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

Sponsor

University Hospital, Basel, Switzerland

Enrollment

300 participants

Start Date

Sep 4, 2018

Study Type

OBSERVATIONAL

Conditions

Multiple Sclerosis (MS)Relapsing-remitting Multiple Sclerosis (RRMS)Secondary-progressive Multiple Sclerosis (SPMS)Primary Progressive Multiple Sclerosis (PPMS)

Summary

This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced MRI brain imaging to better understand how nerve fibers are damaged and then repaired over time in people with multiple sclerosis (MS). Researchers want to find better ways to track disease progression and recovery. **You may be eligible if:** - You are between 18 and 80 years old - You have been diagnosed with relapsing-remitting MS (with active relapses or new lesions on MRI) or progressive MS (either primary or secondary) - You are a healthy volunteer with no neurological or psychiatric conditions (for the control group) **You may NOT be eligible if:** - You are pregnant - You have a contraindication to MRI (such as claustrophobia, a pacemaker, or metal implants) - You are unable to give informed consent - You have another neurological or psychiatric condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMRI

Each enrolled subject will undergo a MRI at baseline and a second MRI at 2 years (+/- 3 months) follow-up.

OTHERNeurocognitive examination for healthy subjects

Neurocognitive examination for healthy subjects will be performed at both baseline and follow-up

OTHERblood sampling

Each enrolled subject will undergo a blood sampling (10 ml) at baseline

Locations(1)

University Hospital Basel, Department of Neurology

Basel, Switzerland

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NCT05177523

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