Multiple Sclerosis (MS) Clinical Trials

15 recruiting

Frequently Asked Questions

Common questions about Multiple Sclerosis (MS) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting
Phase 1Phase 2

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

Multiple SclerosisMultiple Sclerosis (MS) Primary ProgressiveMultiple Sclerosis (MS) Secondary Progressive+2 more
Tr1X, Inc.39 enrolled2 locationsNCT07477639
Recruiting
Phase 4

Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

Multiple SclerosisMultiple Sclerosis (MS) - Relapsing-remitting
Northwestern University40 enrolled1 locationNCT07225361
Recruiting
Phase 1Phase 2

Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy

Multiple Sclerosis (MS)Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary Progressive+4 more
University of California, San Francisco74 enrolled1 locationNCT05359653
Recruiting
Not Applicable

Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study

Multiple Sclerosis (MS) - Relapsing-remittingUpper Extremity Dysfunction
University of Florida15 enrolled2 locationsNCT07376772
Recruiting
Not Applicable

Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences

Multiple Sclerosis (MS)
University Hospital, Basel, Switzerland10 enrolled1 locationNCT04819737
Recruiting
Not Applicable

Effect of Music Therapy on Pain in People With Multiple Sclerosis

Multiple Sclerosis (MS)
Istanbul Bilgi University45 enrolled1 locationNCT06800144
Recruiting
Early Phase 1

Effects of Ublituximab on Motor Functions in Multiple Sclerosis

Multiple Sclerosis (MS) - Relapsing-remitting
Georgia State University25 enrolled2 locationsNCT06629428
Recruiting
Early Phase 1

CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases

Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Daishi Tian36 enrolled1 locationNCT07337785
Recruiting
Not Applicable

Myrosinase Bioactivated Gglucoraphanin for the Treatment of Neurodegenerative Diseases (GRA-MYR-ND)

PARKINSON DISEASE (Disorder)Multiple Sclerosis (MS) - Relapsing-remittingPediatric Patients Affected by Neuromuscolar and Degenerative Diseases
IRCCS Centro Neurolesi Bonino Pulejo300 enrolled1 locationNCT07360977
Recruiting
Not Applicable

Home Based Functional Balance Intervention for Multiple Sclerosis

Multiple SclerosisMultiple Sclerosis (MS) - Relapsing-remittingMultiple Sclerosis (MS) Primary Progressive+2 more
University of Illinois at Chicago75 enrolled1 locationNCT07355387
Recruiting

Escalation vs. Induction Therapy Strategy in Patients With Early-Onset MS After Age 50

Multiple Sclerosis (MS)
University Hospital, Strasbourg, France830 enrolled1 locationNCT07313462
Recruiting
Phase 3

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

Multiple Sclerosis (MS) Primary Progressive
Zenas BioPharma (USA), LLC705 enrolled2 locationsNCT07067463
Recruiting

Multimodal Imaging Signatures of the Biological Mechanisms Underlying Neurodegeneration in Multiple Sclerosis

Multiple Sclerosis (MS)
Assistance Publique - Hôpitaux de Paris80 enrolled1 locationNCT05633875
Recruiting

"Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS

Multiple SclerosisMS (Multiple Sclerosis)Multiple Sclerosis (MS) - Relapsing-remitting+3 more
University of California, San Francisco300 enrolled1 locationNCT07222618
Recruiting

Sexual Dysfunction in Women With Multiple Sclerosis (MS)

Sexual DisfunctionDepressionCognitive Dysfunction+6 more
Ege University140 enrolled1 locationNCT07193823
Recruiting
Phase 1Phase 2

A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis

Multiple Sclerosis (MS)
The Hospital for Sick Children20 enrolled1 locationNCT04121468
Recruiting
Not Applicable

A Palliative Care Model Impact on Knowledge and Attitudes

Multiple Sclerosis (MS)
Hunter College of City University of New York50 enrolled2 locationsNCT06860932
Recruiting

Vista Protein Expression of Monocyte and T Cell Subsets in Multiple Sclerosis and Its Clinical Correlation

Multiple Sclerosis (MS)
Koç University60 enrolled2 locationsNCT06957145
Recruiting
Phase 1

A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy

Myasthenia GravisSystemic Lupus Erythematosus (SLE)Multiple Sclerosis (MS)+3 more
RenJi Hospital30 enrolled1 locationNCT06249438
Recruiting
Phase 1

A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases

Myasthenia GravisMultiple Sclerosis (MS)Neuromyelitis Optica Spectrum Disease (NMOSD)+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology37 enrolled3 locationsNCT06869278